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Cysteine and cystine constitute the most abundant extracellular low-molecular-weight thiol/disulfide couple, apparently functioning in the regulation of protein Cys on the extracellular surface.
References provide detailed information on the interactions of Cys proteins and functional Cys residues: Trx R–actin , Trx-dependent regulation of proteins , Ref1–AP1 , Trx R/AP1 , PDGFR , x CT , PTEN–Trx [262,263], PTEN–GSH , ASK1–Trx2 , GSTp1–Prx6 , GAPDH–GSH [266,267], ND–GSH , p53–Trx , Trx2–Prx3 , Srx–Prx1 and Srx–Prx3 [271,272], Grx2–Prx3 , Grx2–Prx3–Trx2 , PDI–UPR sensor , Era–PDI , PDI–TF , Ero-α-PDI and GSH , GPx7–ER , Nrf2 regulatory Cys residues , Srx functional Cys residues .
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